Insidious Transmission of a Stress-Related Neuroadaptation

Steger, Jennifer S. and Land, Benjamin B. and Lemos, Julia C. and Chavkin, Charles and Phillips, Paul E. M. (2020) Insidious Transmission of a Stress-Related Neuroadaptation. Frontiers in Behavioral Neuroscience, 14. ISSN 1662-5153

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Abstract

Stress is highly pervasive in humans, impacting motivated behaviors with an enormous toll on life quality. Many of the effects of stress are orchestrated by neuropeptides such as corticotropin-releasing factor (CRF). It has previously been shown that in stress-naïve male mice, CRF acts in the core of the nucleus accumbens (NAc) to produce appetitive effects and to increase dopamine release; yet in stress-exposed male mice, CRF loses its capacity to modulate NAc dopamine release and is aversive. In the current research, we tested whether this effect is comparable in females to males and whether the neuroadaptation is susceptible to social transmission. We found that, like in males, CRF increased dopamine release in stress-naïve but not stress-exposed female mice. Importantly, this persistent physiological change was not accompanied by overt behavioral changes that would be indicative of depression- or anxiety-like phenotype. Nonetheless, when these mice were housed for 7 days with stress-naïve conspecifics, the cage mates also exhibited a loss of dopamine potentiation by CRF. These data demonstrate the asymptomatic, yet pervasive transmission of stress-related neuroadaptations in the population.

Item Type: Article
Subjects: Eurolib Press > Biological Science
Depositing User: Managing Editor
Date Deposited: 03 Mar 2023 06:24
Last Modified: 11 May 2024 08:38
URI: http://info.submit4journal.com/id/eprint/1190

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