Khabade, Swapnali and Rathi, Bharat and Rathi, Renu and Chaudhary, Piyush (2022) Pharmaceutico Analytical Study of Roudra Rasa and Evaluation of Its Anti-Carcinogenic Effect in Selected Cell Lines and Acute Toxicity Studies in Albino Wistar Rats: A Study Protocol. Journal of Pharmaceutical Research International, 34 (59). pp. 39-47. ISSN 2456-9119
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Abstract
Introduction: There are expected to have become 1.9 million new cancer diagnoses and 609,360 cancer - related deaths in 2022, or about 1,670 mortality each day. Regardless of human development level, throughout the world, the disease is a leading source of morbidity and mortality. Cancer like disorders have been documented also in Indian subcontinent since antiquity. In the 19th century, the very first cancer cases were diagnosed, and the burden of cancer began to climb in the 20th century, when current treatment facilities were severely inadequate. Roudra Rasa is a special Ayurvedic preparation for Arbuda (Cancer) mentioned in Bhaishajya Ratnavali. It has already been tested clinically in Oropharengeal cancer, with Ayurvedic treatment incorporating Roudra Rasa showing a greater benefit. Cancer cell lines of human are useful models for exploring cancer biology and testing the treatment effectiveness of anti - cancer drugs in the lab. That’s why Michigan Cancer Foundation-7 (MCF-7 - Breast), Human Colorectal Adenocarcinoma Cell Line (HT-29 - Colon), Human Lung Adenocarcinoma (HOP-62), Lung cancer epthelial cell (A549 - Lung), and cell line from prostate carcinoma (DU145), prostate cancer cell line (PC-3 - Prostate), these cancer cell lines have chosen to examine Roudra Rasa's anti cancer activity.
Aim and Objectives: Pharmaceutico analytical study of Roudra Rasa and evaluation of its Anti-carcinogenic And acute toxicity studies in selective cell lines and albino Wistar rats respectively.
Materials and Methods: Roudra Rasa will be prepared by traditional method and quality control parameters will be assessed. Anti-carcinogenic activity will be carried out in selected cancer cell lines. and acute toxicity testing will be done in accordance with OECD guidelines 423.
Observations and Results: Observations of pharmaceutical, analytical and experimental studies will be noted and presented in the forms of table, charts, photographs etc.
Conclusion: If Roudra Rasa shows any significant Anti-Carcenogenic activity then it would be safe and efficient medicine for Cancer.
Item Type: | Article |
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Subjects: | Eurolib Press > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 05 Jan 2023 12:03 |
Last Modified: | 05 Mar 2024 03:51 |
URI: | http://info.submit4journal.com/id/eprint/1224 |