Mele, Giuseppe and D’Agostino, Grazia and Loseto, Giacomo and Coppi, Maria Rosaria and Melpignano, Angela and Angone, Grazia and Quarta, Giovanni (2012) Whole-Body 64-Slice Multidetector Computed Tomography (MDCT) Identifies High-Risk Myeloma. International Journal of Clinical Medicine, 03 (07). pp. 644-649. ISSN 2158-284X
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Abstract
Background: In Multiple Myeloma (MM) the individuation of bone lesions at baseline is mandatory because the detection of cortical damage reflects prognostic implications. Conventional Radiography (CR) shows osteolytic bone lesions only when the cortical bone damage is more than 30%. Whole-body 64-slice multidetector computed tomography (MDCT) has recently been employed for detecting early osteolytic disease. Patients and Methods: Twenty-height patients with Asymptomatic MM according to IMWG criteria underwent a 64 MDCT. Results: In our experience MDCT revealed osteolysis in 14/28 patients with normal skeletal survey and in 6 patients with normal Magnetic Resonance Imaging (MRI). Patients with radiological evidence of bone disease on MDCT were at high risk of progression with a median time to progression of 5 months (range 1 - 26 months) in comparison with patients without radiological evidence of bone disease who, conversely, showed a median time to progression of 20 months (range 8 - 40 months) (P = 0.0001). Conclusions: MDCT is able to identify MM patients with a high risk of progression, who might benefit from early therapy.
Item Type: | Article |
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Subjects: | Eurolib Press > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 24 Jan 2023 05:23 |
Last Modified: | 24 May 2024 05:23 |
URI: | http://info.submit4journal.com/id/eprint/1236 |