Comparison between Efficacy of Carboxytherapy, Plasma Gel Injection and Mesotherapy in Treatment of Periorbital Dark Circles

Background: Periorbital dark circles (PODC) is also recognized as periorbital melanosis, dark eye circles, and infraorbital darkness. It`s a public cosmetic skin disorder with relative darkness of the periorbital areas. This condition affects both sexes, it gets worse by aging which makes people look tired and older, so it has a negative effect on the quality of life, particularly in Women.

Methods: This comparative, simple randomized, controlled study was carried out on 30 patients with presented with periorbital dark circles did not receive any treatment 3 months before joining the study. The patients were equally allocated into three groups Group A: treated with bilateral injection of PRP gel, Group B: treated with bilateral intradermal injection of CO2 with carboxytherapy machine and Group C: treated with intradermal injection of vitamin C. All patients received 4 sessions with 2 weeks a part.

All patients were subjected to complete history taking, general and dermatological examination and clinical assessment was done for all patients to determine the type of dark circles.

Results: The improvement of PODC in Plasma gel injection and carboxytherapy mesotherapy were excellent in (50%) and (40%) in vitamin C group. There was gradual improvement of PODC with time, but recurrence rate of the studied groups after 6 months was 40%, 30%, 60% in group A, B and C respectively, showing higher recurrence rate in group C patients treated with vitamin C mesotherapy.

Conclusions: Gel injection, carboxytherapy and vitamin C mesotherapy were effective and safe therapeutic modalities in treatment of PODC.