Evaluation of CNS Depressant, Antidiarrheal and Antipyretic Activities of Ethanolic Leaf Extract of Calophyllum inophyllum L. on Swiss Albino Mice

Objective: The main objective of the present study was to evaluate the CNS depressant, antidiarrheal and antipyretic activities of ethanolic leaf extract of Calophyllum inophyllum L.

Methods: In the present study CNS depressant activity of C. inophyllum was carried out using hole-cross, hole-board and open-field models in swiss albino mice whereas castor-oil induced diarrhea was used to evaluate antidiarrheal activity. The antipyretic activity was conducted by Brewer’s yeast-induced hyperthermia in mice.

Results: The experimental result indicates that the ethanolic extract of C. inophyllum induced CNS depression significantly (p<0.05) in tested animals and the observed effect was dose dependent comparable to standard drug diazepam. The plant extract at the dose of 250 and 500 mg/kg body weight showed significant inhibition of 41.66% and 62.19% in castor oil-induced diarrheal method. In yeast-induced pyrexia, the plant extract displayed dose-dependent inhibition as compared to paracetamol.

Conclusion: This study concludes that C. inophyllum leaf has significant CNS depressant, antidiarrheal and antipyretic activities which provide scientific support for its medicinal applications.