Mpiana, P and Kasali, F and Bwirhonde, F and Gbolo, B and Tshibangu, D and Ngbolua, K and Memvanga, P and Kadima, J (2016) Acute and Sub-acute Oral Toxicity Study of Drepanoalpha® (A Poly-Herbal Formula Used in the Management of Sickle Cell Disease) in Guinea-pigs. British Journal of Pharmaceutical Research, 10 (5). pp. 1-8. ISSN 22312919
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Abstract
Aims: To deepen the toxicological investigation of Drepanoalpha®, a poly-herbal formula used for its antisickling and radical scavenging properties in Congolese traditional medicine.
Study Design: To evaluate lethality, biochemical alterations, behavioral disturbances in guinea-pigs orally given increasing doses of Drepanoalpha® aqueous extracts.
Place and Duration of Study: Faculty of Medicine and Pharmacy, Official University of Bukavu, Bukavu, DR Congo, between June to December 2015.
Methodology: The extracts were prepared as aqueous decoctions of Drepanoalpha powder. Animals were set to groups of 3 animals each. The doses varied from 250 mg to 16000 mg/kg body weight. Acute toxicity had to be estimated by LD50. Sub-acute toxicity was carried out by giving fractionated doses of Drepanoalpha extract during 2 weeks. Changes in blood biomarkers and behavioral signs were evaluated from baseline values of control untreated animals.
Results: Up to 16000 mg/kg, no death was recorded in acute toxicity. Thus, LD50 was not calculated. No significant changes in animals behavioral were observed during sub-acute testing. Instead, body weight gain, blood cell counts increase, BUN and ALT decrease, no change in serum creatinine were noted.
Conclusion: The findings comfort the safety of Drepanoalpha as found previously studies in rats.
Item Type: | Article |
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Subjects: | Eurolib Press > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 02 Jun 2023 04:09 |
Last Modified: | 15 Jan 2024 04:05 |
URI: | http://info.submit4journal.com/id/eprint/1988 |