Fornaro, Michele and Tokumitsu, Keita and Norio, Yasui-Furukori and Adachi, Naoto and Kubota, Yukihisa and Watanabe, Yoichiro and Miki, Kazuhira and Azekawa, Takaharu and Edagawa, Koji and Katsumoto, Eiichi and Hongo, Seiji and Goto, Eiichiro and Ueda, Hitoshi and Kato, Masaki and Nakagawa, Atsuo and Kikuchi, Toshiaki and Tsuboi, Takashi and Watanabe, Koichiro and Shimoda, Kazutaka and Yoshimura, Reiji (2021) Real-world clinical predictors of manic/hypomanic episodes among outpatients with bipolar disorder. PLOS ONE, 16 (12). e0262129. ISSN 1932-6203
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Abstract
Background
Bipolar disorder is a mental illness in which manic and depressive states are repeated, causing psychosocial dysfunction. Manic/hypomanic episodes cause problems with interpersonal, social and financial activities, but there is limited evidence regarding the predictors of manic/hypomanic episodes in real-world clinical practice.
Methods
The multicenter treatment survey on bipolar disorder (MUSUBI) in Japanese psychiatric clinics was administered in an observational study that was conducted to accumulate evidence regarding bipolar disorder in real-world clinical practice. Psychiatrists were asked to complete a questionnaire about patients with bipolar disorder who visited 176 member clinics of the Japanese Association of Neuro-Psychiatric Clinics by conducting a retrospective medical record survey. Our study extracted baseline patient characteristics from September to October 2016, including comorbidities, mental status, duration of treatment, Global Assessment of Functioning (GAF) score, and pharmacological treatment details. We investigated the presence or absence of manic/hypomanic episodes over the course of one year from baseline to September-October 2017.
Results
In total, 2231 participants were included in our study, 29.1% of whom had manic/hypomanic episodes over the course of one year from baseline. Binomial logistic regression analysis revealed that the presence of manic/hypomanic episodes was correlated with lower baseline GAF scores, rapid cycling, personality disorder, bipolar I disorder, and a mood state with manic or mixed features. Substance abuse was also a risk factor for manic episodes. There was no significant association between a baseline antidepressant prescription and manic/hypomanic episodes.
Conclusions
In Japan, 29.1% of outpatients with bipolar disorder had manic/hypomanic episodes over the course of one year. Our study suggested that a low GAF score, rapid cycling, personality disorder, bipolar I disorder, substance abuse, and baseline mood state could be predictors of manic/hypomanic episodes. Based on our findings, an antidepressant prescription is not a predictor of manic/hypomanic episodes.
Item Type: | Article |
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Subjects: | Eurolib Press > Biological Science |
Depositing User: | Managing Editor |
Date Deposited: | 11 Sep 2023 10:02 |
Last Modified: | 11 Sep 2023 10:02 |
URI: | http://info.submit4journal.com/id/eprint/2316 |