Worsening Hypothyroidism in a Patient with Nephrotic Syndrome - A Case Report

The therapy of patients may be complicated by the coexistence of nephrotic syndrome and hypothyroidism, which might exacerbate the thyroid condition. In this case report, a 55-year-old woman with previously well-controlled hypothyroidism is described. Her symptoms deteriorated as a result of recently discovered nephrotic syndrome. Increased gut edema and urine loss of thyroxine-binding globulin were likely to blame for the hypothyroidism's worsening, as well as changed levothyroxine absorption. The patient's symptoms improved after receiving more levothyroxine and the proper care for nephrotic syndrome, which was shown by lower levels of thyroid-stimulating hormone. This instance highlights the significance of taking nephrotic syndrome into account as a potential reason for patients' hypothyroidism to worsen when they are receiving levothyroxine therapy.