A Study on Transdermal Drug Delivery Systems Containing Eplerenone: Formulation, Optimization, and Characterization

The proposed work aims to optimize the formulation and characterisation of eplerenone transdermal patches for efficient transdermal distribution and to improve eplerenone's antihypertensive impact. Skin penetration energy is critical to the successful enhancement of the transdermal restorative framework. Transdermal medication saturation contains the following advances: sorption by the layer corneum, medication infiltration through the feasible epidermis, and medication uptake by a narrow organization in the dermal papillary layer. Transdermal medication conveyance frameworks (TDDS) are measurements structures that include drug transport to potentially epidermal or dermal tissues of the skin for local restorative impact while a significant portion of medication is shipped into the fundamental blood course. The log p estimate for eplerenone is 1.34, which is close to the usual value. A log P value in the range of 1 to 4 suggests greater skin permeability. The FTIIR study compared eplerenone and FTIR spectra of pure medication and polymer. The eplerenone calibration curve in Phosphate buffer pH 6.8 was investigated. Eplerenone nanoparticles were effectively formed into transdermal patches using HPMC and Eudragit RS 100. The physical characterisation of Eplerenone nanoparticle transdermal patches revealed that the patches were uniform. Eplerenone is capable of penetrating the skin and forming eplerenone nanoparticles. Overall, the results of this study demonstrate that the restriction of oral eplerenone delivery may be overcome by incorporating eplerenone nanoparticles transdermal patches for antihypertensive medication.