Safety and Tolerability of Some Second Generation of Antipsychotics

To monitor ADRs of second generation antipsychotics and find out the causality and severity of ADRs related to the second generation antipsychotics. An antipsychotic drug is a psychiatric tranquillizer typically prescribed to treat psychosis, schizophrenia, bipolar disorder, delusions, paranoid disorder, mental retardation, depression, and other mental health conditions. These medications are also used to treat non-psychotic disorders. The drugs in the second generation came later and are known as atypical antipsychotics. The first generation of antipsychotics, also known as typical antipsychotics, were discovered in the 1950s. In the present study 100 patients were screened, of whom 91 (91.00%) were suspected to suffer from adverse drug reactions (ADRs). Four atypical antipsychotic drugs were most frequently used such as olanzapine (5mg, 10mg), risperidone (2mg, 1mg), clozapine (0.5mg) and quetiapine (50 mg). Information about ADRs was gathered simultaneously from patients' guardians and patients themselves. The format created by the Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, allowed for the entry of information regarding the study of prescribed medications, various adverse reactions, the management of ADR, as well as reports of laboratory investigations. Total 171 adverse events were investigated and tabulated. Causality of adverse events was assessed by Naranjo's algorithm and World Health Organization-Uppsala Monitoring Centre (WHO-UMC) criteria. The results of the current study and the documented ADR reports may be useful for future researchers to conduct additional research in this area and to inform clinicians about the ADR profile of the otherwise widely prescribed class of antipsychotic drugs.