EVALUATION OF CYTOTOXICITY AND ANTI-CANCER ACTIVITY OF Solanum torvum STEM EXTRACT ON NORMAL VERO AND HUMAN BREAST CANCER MCF - 7 CELL LINE

Limited plants have been screened for their complete biological and pharmacological nature. In the present research investigation an attempt was made to decipher the medicinal value of aqueous extract of Solanum torvum (S.torvum) stem. Phytochemical screening of the aqueous extract of S.torvum stem in the present study ascertain the presence of flavonoids, phenols, saponins, alkaloids, coumarins, sterols, proteins and reducing sugars. Further, the potentiality of aqueous extract of S.torvum stem was assessed for its cytotoxic effect on Normal Vero cell line and anticancer activity on Human breast adenocarcinoma cell line by 3-(4,5dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide assay and compared with normal drug target doxorubicin. A 24-hour incubation cell proliferation study reduced the cell viability of MCF-7 breast cancer cell lines. In vitro studies on cytotoxicity analysis on Vero cell line revealed that the aqueous stem extract of S.torvum show mild toxicity and further it was found to be effective in the prevention of cell proliferation by MCF-7 cell lines.