A New Convenient Synthesis of Tetra Substituted Pyrimidines and Their Antimicrobial Screening Report

An efficient and novel strategy has been developed using potassium carbonate as catalyst for
synthesis of 4-amino-2-methyl-6-(methylthio)pyrimidine-5-carbonitrile (3) by condensing acetamidine
hydrochloride (1) with bis(methylthio)methylene malononitrile (2) in DMF. Compound (3) is susceptible
to nucleophilic substitution reaction due to presence of methylthio group at sixth position, which is
replaced by different nucleophiles such as substituted anilines, phenols, hetryl amines and
compounds containing active methylene group to afford 6-substituted derivatives of 4-amino-2-methyl-
6-(methylthio)pyrimidine-5-carbonitriles (4a-7d). All newly prepared compounds were characterized by
IR, 1H-NMR, Mass spectral analysis. Furthermore, these synthesized compounds were tested for
antimicrobial activity. This procedure offers the advantages of mild reaction condition, easy work up,
short reaction time and high yield.