An Overview: Global Sensitivity Analysis in Physiological Systems

Pharmacokinetic models are mathematical models which provide insights into the interaction of
chemicals with biological processes. During recent decades, these models have become central of
attention in industry that caused to do a lot of efforts to make them more accurate. Current work
studies the process of drug and nanoparticle (NPs) distribution throughout the body which consists of
a system of ordinary differential equations. We use a tri-compartmental model to study the perfusion
of NPs in tissues and a six-compartmental model to study drug distribution in different body organs.
We have performed global sensitivity analysis by LHS Monte Carlo method using PRCC. We identify
the key parameters that contribute most significantly to the absorption and distribution of drugs and
NPs in different organs in body. We have presented another physiological model with six
compartments, such as kidney, liver, lung, fat, muscle and plasma compartment. We identified the key
parameters that contribute most significantly to the absorption and distribution of drugs in different
organs in body using PRCC. Our findings imply that this identification is clearly dependent upon the
dose and target tissues but not on the exposure route