THE INFLUENCE OF THYROID HORMONES ON THE CARDIOVASCULAR SYSTEM BY MONITORING SOME PARAMETERS OF LIPOPROTEIN METABOLISM

Thyroid hormones regulate the activity of enzymes that play keyrole in the metabolism of lipoproteins. Thyroid dysfunction resulting in lipid abnormalities. Atherogenic lipid profile indicate an increased risk of cardiovascular disease.

In this work was tested the impact of thyroid disorders on lipid profile and association with risk of cardiovascular disease in atherosclerotic hypothyroid (n=40) and hyperthyroid (n=40) patients, men and women at random, and euthyroid-healthy subjects (n=60, control group). Thyreostimulating hormone (TSH), free thyroxine (fT4), low density lipoprotein (LDL), high density lipoprotein (HDL) were studied in three groups of respondents with standardized tests.

The results showed that hypothyroid patients have significantly higher values of LDL-cholesterol (p<0,05) compared with euthyroid group. In hyperthyroid patients have significantly lower values of LDL-cholesterol in males (p<0,05) in contrast to euthyroid respondents, while the females are statistically insignificant elevated. As for HDL-cholesterol, its values are significantly smaller (p<0,05) in both groups compared with control group.

Results also indicate that females in hypothyroid and hyperthyroid patients have higher values cholesterol of LDL-unlike male gender. HDL- cholesterol in hyperthyroid men is significantly smaller than females. This significant difference is observed in hyporhyroid men and women.

The summarized results showed that hypothyroid patients due to abnormal atherogenic lipid levels are at greater risk of atherosclerotic cardiovascular disease.