Araújo, Chrisjacele Santos Ferreira de and Araújo, Tiago Ferreira da Silva and Silva, Cleideana Bezerra da and Campos, Janaina Karin de Lima and Paiva, Patrícia Maria Guedes and Napoleão, Thiago Henrique and Lima, Vera Lúcia de Menezes and Coelho, Luana Cassandra Breitenbach Barroso (2019) Evaluation of Toxicity on Mice and Artemicidal Activity of Bauhinia monandra Leaf Lectin (BmoLL). In: Theory and Applications of Microbiology and Biotechnology Vol. 1. B P International, pp. 43-52. ISBN 978-93-89562-05-7
Full text not available from this repository.Abstract
Aims: This work aimed to determine the toxicity of Bauhinia monandra leaf lectin (BmoLL) to mice
and Artemia salina.
Study design: BmoLL was purified from the leaves of B. monandra through affinity chromatography
and tested against mice and A. salina in order to evaluate its toxicity.
Methodology: The lectin purification was performed through saline precipitation and chromatography
onto a guar gel column. The acute toxicity of BmoLL was evaluated using female mice during 14
days. Toxicity of BmoLL to A. salina larvae was also evaluated.
Results: BmoLL did not induce death or weight loss of mice at 2000 mg/kg b.w.; additionally, the
lectin did not affect the survival of A. salina at the assayed concentrations (250–1,000 μg/mL).
Conclusion: BmoLL is an interesting molecule to investigate pharmacological applications due to its
low toxicity according to the two models used in this work.
| Item Type: | Book Section |
|---|---|
| Subjects: | Eurolib Press > Social Sciences and Humanities |
| Depositing User: | Managing Editor |
| Date Deposited: | 17 Nov 2023 03:59 |
| Last Modified: | 17 Nov 2023 03:59 |
| URI: | http://info.submit4journal.com/id/eprint/3066 |
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