Hwang, Kyusang and Yoon, Jin Hwan and Lee, Ji Hyun and Lee, Sukmook (2021) Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers. Biomedicines, 9 (1). p. 39. ISSN 2227-9059
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Abstract
Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide. Recent advances in recombinant DNA technology have led to the development of numerous therapeutic antibodies as major sources of blockbuster drugs for CRC therapy. Simultaneously, increasing numbers of therapeutic targets in CRC have been identified. In this review, we first highlight the physiological and pathophysiological roles and signaling mechanisms of currently known and emerging therapeutic targets, including growth factors and their receptors as well as immune checkpoint proteins, in CRC. Additionally, we discuss the current status of monoclonal antibodies in clinical development and approved by US Food and Drug Administration for CRC therapy.
Item Type: | Article |
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Subjects: | Eurolib Press > Biological Science |
Depositing User: | Managing Editor |
Date Deposited: | 28 Nov 2022 06:40 |
Last Modified: | 01 Jul 2024 06:16 |
URI: | http://info.submit4journal.com/id/eprint/440 |