Anticancer-active 3,4-diarylthiolated maleimides synthesis via three-component radical diarylthiolation

Wang, Limei and Li, Zhuo and Ma, Zhehan and Xia, Kedi and Wang, Wenyu and Yu, Wenchang (2022) Anticancer-active 3,4-diarylthiolated maleimides synthesis via three-component radical diarylthiolation. Frontiers in Chemistry, 10. ISSN 2296-2646

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Abstract

Herein, we report an efficient and simple copper-catalyzed oxidative diarylthiolation of maleimides with sulfur powder and aryl boronic acids, in which S powder was used as a substrate and internal oxidant. The corresponding double C-S bonds coupling products were obtained in moderate to high yields under a simple catalytic system. Mechanistic studies indicated that copper-catalyzed radical thiolation of aryl boronic acids with S powder, and the resulting arylthiyl underwent radical addition with double bonds of maleimides.

Item Type: Article
Subjects: Eurolib Press > Multidisciplinary
Depositing User: Managing Editor
Date Deposited: 05 Jan 2023 06:41
Last Modified: 18 May 2024 07:03
URI: http://info.submit4journal.com/id/eprint/634

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