Fukumoto, Shoichi and Shigenobu, Miho and Ishimaru, Kaori (2019) Mannich-Type Reaction of Aldimines with 2-Silyloxydienes Catalyzed by Ammonium Chloride. International Journal of Organic Chemistry, 09 (04). pp. 163-173. ISSN 2161-4687
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Official URL: https://doi.org/10.4236/ijoc.2019.94014
Abstract
Reaction of imines with 2-silyloxydiene catalyzed by ammonium chloride has been perfectly proceeded under environmentally friendly conditions to give Mannich-type product selectively. The reaction would proceed via Mannich-type mechanism, not cyclization/ring-opening process. Cyclopropanation of the corresponding Mannich-type product gave the precursor of prasugrel skeleton in high yield.
| Item Type: | Article |
|---|---|
| Subjects: | Eurolib Press > Chemical Science |
| Depositing User: | Managing Editor |
| Date Deposited: | 25 Feb 2023 07:41 |
| Last Modified: | 04 Jun 2024 10:49 |
| URI: | http://info.submit4journal.com/id/eprint/652 |
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