Uncommon Bis-Amide Matrine-type Alkaloids From Sophora alopecuroides With Anti-inflammatory Effects

Luo, Ding and Tu, Zhenchao and Yin, Wenjing and Fan, Chunlin and Chen, Nenghua and Wu, Zhongnan and Ding, Weilong and Li, Yaolan and Wang, Guocai and Zhang, Yubo (2021) Uncommon Bis-Amide Matrine-type Alkaloids From Sophora alopecuroides With Anti-inflammatory Effects. Frontiers in Chemistry, 9. ISSN 2296-2646

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Official URL: https://doi.org/10.3389/fchem.2021.740421

Abstract

Four new alkaloids (1–4) belonging to rare examples of bis-amide matrine-type were isolated from the seeds of sophora alopecuroides. Their structures including absolute configuration were determined by extensive spectroscopic analysis, electronic circular dichroism (ECD) interpretation, and X-ray diffraction crystallography. Chemically, bis-amide matrine-type alkaloids can provide new molecular template for structural modification. Compounds 3–4 displayed obvious anti-inflammatory effects based on the inhibition of two key pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)] in a dose-dependent manner, with IC50 values from 35.6 to 45.8 μm.

Item Type:	Article
Subjects:	Eurolib Press > Chemical Science
Depositing User:	Managing Editor
Date Deposited:	20 Mar 2023 04:55
Last Modified:	23 May 2024 05:35
URI:	http://info.submit4journal.com/id/eprint/814

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