Akula, Murthy R. and Marepally, Srinivasa R. and Collier, Lee T. and Kabalka, W. George (2016) Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow Chemistry. International Journal of Organic Chemistry, 06 (03). pp. 177-185. ISSN 2161-4687
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Abstract
[F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.
Item Type: | Article |
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Subjects: | Eurolib Press > Chemical Science |
Depositing User: | Managing Editor |
Date Deposited: | 21 Mar 2023 05:40 |
Last Modified: | 24 Jun 2024 04:11 |
URI: | http://info.submit4journal.com/id/eprint/975 |